Cerebrovascular changes and prevalence of vascular risk factors across
different neurodegenerative diseases
 
   Lead Investigator:    Jon Toledo
   Institution      :    CNDR, UPenn School of Medicine
   E-Mail           :    jtoledo@mail.med.upenn.edu
   Proposal ID      :    233


   Publications:


1  Toledo JB, Arnold SE, Raible K, Brettschneider J, Xie SX, Grossman M,  Monsell SE, Kukull WA , Trojanowski JQ
   Contribution of cerebrovascular disease in autopsy confirmed neurodegenerative disease cases in the National Alzheimer's Coordinating Centre
   Journal Article  Brain,136:2697-2706,2013,PMC3858112

   PUBLISHED





   Proposal Description:
   Evidence from epidemiological and experimental studies has associated Alzheimers disease to vascular risk factors (VRF) and and cerebrovascular disease (CVD). However, there is no evidence of this association across different neurodegenerative diseases, like frontotemporal lobar degeneration (FTLD) tau and FTLD-TDP43 and other less frequent neurodegenerative diseases. This is difficult due to the lower prevalence of these diseases and the low agreement of the clinical diagnosis with the neuropathological diagnosis together with the absence of reliable biomarkers for the FTLD spectrum (Toledo et al, Acta Neuroptahologica 2012). Therefore, the NACC database offers a great resource to study the presence of CVD in the FTLD, Lewy body disease, multiple system atrophy and other diseases and the prevalence of VRF in theses patients.